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Studies do not permit conclusions as to the relative importance of the medication and non-drug factors on weight loss.
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The amount of weight loss is related with the use of an “anorectic” drug varies from trial to trial, and the increased weight loss appears to be related in part to variables other than the drugs prescribed, such as the physician-investigator, the population treated and the diet prescribed.
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The rate of weight loss is at it’s peak in the first weeks of therapy for both drug and placebo subjects and tends to decrease in succeeding weeks.